Crizalk 250mg Capsule - Crizotinib Uses & Side effects

CRIZALK 250MG




DESCRIPTION


Crizalk 250mg capsule belongs to type of tyrosine kinase inhibitor. Kinases are enzymes which are included in many functions, involving cell development and reproduction.

Crizalk 250mg is made specifically for the treatment of a type of lung cancer in which ALK is overactive due to an abnormality in the ALK gene.

Crizalk 250mg is a prescription drug which is used under the supervision of medical practioner.


PRODUCT DETAILS


Brand Name                 Crizalk 
Composition                Crizotinib 
Strength availability    250mg 
Manufactured by         Pfizer Ltd 
Form                           Capsules 
Pack                            60 capsules


MECHANISM OF ACTION



  • Particularly, crizotinibprevents anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteurd'OrigineNantais (RON). 
  • Malformations in the ALK gene result by mutations or translocations may leads expression of oncogenic fusion proteins. somepatients with NSCLC, they have the EML4-ALK gene.
  • Crizotinib inhibits ALK tyrosine kinase which essentially results in decreasedproliferation of cells which carry the genetic mutation and tumour survivability.



DRUG INTERACTION


  • Crizalk 250mg Combination with strong or moderate CYP3A4 inhibitors will increase Crizalk plasma concentration.
  • Crizalk200mg concomitant use with strong CYP3A inducers will decrease Crizalk plasma concentration.
  • Crizalk 250mg Interaction with CYP3A substrates will increase plasma concentration of CYP3A substrates.
  • Do not use combination with bradycardia causing drugs.


SIDE EFFECTS


Crizalk is caused some side effects as follows :
• Infection increased
• Breathlessness
• Eyesight changes
• Bowel changes
• Feeling sick
• Swelling of hands and feet’s
• Decreased appetite
• Fatigue
• Liver changes
• Skin rash
• Bradycardia



PRESCRIPTION POLICY

Myapplepharma.com, a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines. 

Comments

Post a Comment

Popular posts from this blog

Herduo 250mg tablet: Lapatinib Uses & Side effects | Apple pharmaceuticals

HERDUO 250MG Herduo 250 mg tablets are classified as anti-cancer agent, which is orally active drug used for treating breast cancer. Herduo tablets are classified as; 1. Tyrosine kinase prohibitor 2. Stop the HER2/neu& epidermal growth factor receptor activity 3. Targeted therapy  4. Signal transduction prohibitor. PRODUCT DETAILS Brand Name : Herduo  Composition : Lapatinib   Strength availability : 250mg  Manufactured by : Natco Pharma Pack : 150 tablets PHARMACOLOGY Absorption: Incomplete and insufficient absorption, the time to peak plasma concentration is 4 hours after intake of drug. Distribution : The drug bounds to human plasma protein like albumin & alpha glycoprotein relatively 99%. Metabolism : Herduo is a substrate of P-gp& BCRP and go through intensive metabolism by using CYPP3A4 & CYP3A5 with minimum contribution of CYP2C19 & CYP2C8. Excretion : Elimination occurs via feces...
Read more

Glenza 40mg Tablet (Enzalutamide) Price, Uses & Side effects

Image
GLENZA 40MG Glenza is a hormonal therapy, for men who are all affected with prostate carcinoma in metastaic stage. Glenza 40mg Capsules are majorly indicated for prostate carcinoma, which contains Enzalutamide, as an active component considered as non steroidal anti-androgen medication. PRODUCT DETAILS Brand name : Glenza  Active ingredient : Enzalutamide  Strength :40MG  COMPANY NAME : Glenmark TAB COUNT : 28 tablets Glenza 40mg Mechanism of Action An androgen which is a male hormone is used to develop prostate carcinoma. One of the major hormone secreted by testes and adrenal glands is known as testosterone. Glenza containing Enzalutamide will interfere with testosterone production, causes tumor cell growth depletion. Glenza interfere with androgen receptor signaling transduction and leads to cancer cell lysis. DOSAGE DOSING CONDITIONS AND ADMINISTRATION  The usual prescribed dosage of Glenza is 160mg as a singl...
Read more

Azel 40mg tablet (Enzalutamide) Price, Uses & Side effects

Image
AZEL 40MG Azel is a hormonal therapy, for men who are all affected with prostate carcinoma in metastaic stage. Azel 40mg Capsules are majorly indicated for prostate carcinoma, which contains Enzalutamide , as an active component considered as non steroidal anti-androgen medication. PRODUCT DETAILS Brand name : Azel  Active ingredient : Enzalutamide  Strength :40MG  Manufactured by : Dr.Reddy’s laboratories Package : 28 capsules  Category : Anti-neoplastic agent Azel 40mg tablet DOSAGE The usual prescribed dosage of Azel is 160mg as a single dose by taking with or without food. Azel is available in the strength of 40mg; four Capsules of Azel should be administered at a same time. Azel Capsule should not crush, not chew taken with glass of water. Dose adjustment: In patients with ≥ grade III toxicity: Azel 40mg therapy should be refuse for one week or the symptoms should be reduced to grade II, then restart with same dose ...
Read more