Crizalk 250mg Capsule - Crizotinib Uses & Side effects

CRIZALK 250MG




DESCRIPTION


Crizalk 250mg capsule belongs to type of tyrosine kinase inhibitor. Kinases are enzymes which are included in many functions, involving cell development and reproduction.

Crizalk 250mg is made specifically for the treatment of a type of lung cancer in which ALK is overactive due to an abnormality in the ALK gene.

Crizalk 250mg is a prescription drug which is used under the supervision of medical practioner.


PRODUCT DETAILS


Brand Name                 Crizalk 
Composition                Crizotinib 
Strength availability    250mg 
Manufactured by         Pfizer Ltd 
Form                           Capsules 
Pack                            60 capsules


MECHANISM OF ACTION



  • Particularly, crizotinibprevents anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteurd'OrigineNantais (RON). 
  • Malformations in the ALK gene result by mutations or translocations may leads expression of oncogenic fusion proteins. somepatients with NSCLC, they have the EML4-ALK gene.
  • Crizotinib inhibits ALK tyrosine kinase which essentially results in decreasedproliferation of cells which carry the genetic mutation and tumour survivability.



DRUG INTERACTION


  • Crizalk 250mg Combination with strong or moderate CYP3A4 inhibitors will increase Crizalk plasma concentration.
  • Crizalk200mg concomitant use with strong CYP3A inducers will decrease Crizalk plasma concentration.
  • Crizalk 250mg Interaction with CYP3A substrates will increase plasma concentration of CYP3A substrates.
  • Do not use combination with bradycardia causing drugs.


SIDE EFFECTS


Crizalk is caused some side effects as follows :
• Infection increased
• Breathlessness
• Eyesight changes
• Bowel changes
• Feeling sick
• Swelling of hands and feet’s
• Decreased appetite
• Fatigue
• Liver changes
• Skin rash
• Bradycardia



PRESCRIPTION POLICY

Myapplepharma.com, a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines. 

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