Apple pharmaceuticals

LAPAHOPE  250MG Lapahope 250 mg tablets  are classified as anti-cancer agent, which is orally active drug used for treating breast cancer. Herduo tablets are classified as; 1. Tyrosine kinase prohibitor 2. Stop the HER2/neu& epidermal growth factor receptor activity 3. Targeted therapy  4. Signal transduction prohibitor. PRODUCT DETAILS Brand Name : Lapahope Composition :  Lapatinib Strength availability : 250mg  Manufactured by : Glenmark Pharma Pack : 150 tablets PHARMACOLOGY Absorption: Incomplete and insufficient absorption, the time to peak plasma concentration is 4 hours after intake of drug. Distribution : The drug bounds to human plasma protein like albumin & alpha glycoprotein relatively 99%. Metabolism : Lapahope is a substrate of P-gp& BCRP and go through intensive metabolism by using CYPP3A4 & CYP3A5 with minimum contribution of CYP2C19 & CYP2C8. Excretion : Elimination occurs via feces & urine.

HERDUO 250MG Herduo 250 mg tablets are classified as anti-cancer agent, which is orally active drug used for treating breast cancer. Herduo tablets are classified as; 1. Tyrosine kinase prohibitor 2. Stop the HER2/neu& epidermal growth factor receptor activity 3. Targeted therapy  4. Signal transduction prohibitor. PRODUCT DETAILS Brand Name : Herduo  Composition : Lapatinib   Strength availability : 250mg  Manufactured by : Natco Pharma Pack : 150 tablets PHARMACOLOGY Absorption: Incomplete and insufficient absorption, the time to peak plasma concentration is 4 hours after intake of drug. Distribution : The drug bounds to human plasma protein like albumin & alpha glycoprotein relatively 99%. Metabolism : Herduo is a substrate of P-gp& BCRP and go through intensive metabolism by using CYPP3A4 & CYP3A5 with minimum contribution of CYP2C19 & CYP2C8. Excretion : Elimination occurs via feces & urine. Hal

CRIZALK 250MG DESCRIPTION Crizalk 250mg capsule belongs to type of tyrosine kinase inhibitor. Kinases are enzymes which are included in many functions, involving cell development and reproduction. Crizalk 250mg is made specifically for the treatment of a type of lung cancer in which ALK is overactive due to an abnormality in the ALK gene. Crizalk 250mg is a prescription drug which is used under the supervision of medical practioner. PRODUCT DETAILS Brand Name                 Crizalk  Composition                Crizotinib  Strength availability    250mg  Manufactured by         Pfizer Ltd  Form                           Capsules  Pack                            60 capsules MECHANISM OF ACTION Particularly, crizotinibprevents anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-MET), and Recepteurd'OrigineNantais (RON).  Malformations in the ALK gene result by mutations or translocations may leads expressi

CRIZALK 200MG DESCRIPTION Crizalk 200mg capsule belongs to type of tyrosine kinase inhibitor. Kinases are enzymes which are included in many functions, involving cell development and reproduction. Crizalk 200mg is made specifically for the treatment of a type of lung cancer in which ALK is overactive due to an abnormality in the ALK gene. Crizalk 200mg is a prescription drug which is used under the supervision of medical practitioner. PRODUCT DETAILS Brand Name                  Crizalk Composition                  Crizotinib   Strength availability      200mg  Manufactured by           Pfizer Ltd  Form                             Capsules  Pack                              60 capsules PRECAUTION Before using Crizalk in some condition, consult with doctor. Hepatotoxicity causes while treatment with Crizalk while treatment with Crizalk will causes Interstitial lung disease/pneumonitis. QT interval prolongation Bradycardia  Severe

GLENZA 40MG Glenza is a hormonal therapy, for men who are all affected with prostate carcinoma in metastaic stage. Glenza 40mg Capsules are majorly indicated for prostate carcinoma, which contains Enzalutamide, as an active component considered as non steroidal anti-androgen medication. PRODUCT DETAILS Brand name : Glenza  Active ingredient : Enzalutamide  Strength :40MG  COMPANY NAME : Glenmark TAB COUNT : 28 tablets Glenza 40mg Mechanism of Action An androgen which is a male hormone is used to develop prostate carcinoma. One of the major hormone secreted by testes and adrenal glands is known as testosterone. Glenza containing Enzalutamide will interfere with testosterone production, causes tumor cell growth depletion. Glenza interfere with androgen receptor signaling transduction and leads to cancer cell lysis. DOSAGE DOSING CONDITIONS AND ADMINISTRATION  The usual prescribed dosage of Glenza is 160mg as a single dose by taking wi

AZEL 40MG Azel is a hormonal therapy, for men who are all affected with prostate carcinoma in metastaic stage. Azel 40mg Capsules are majorly indicated for prostate carcinoma, which contains Enzalutamide , as an active component considered as non steroidal anti-androgen medication. PRODUCT DETAILS Brand name : Azel  Active ingredient : Enzalutamide  Strength :40MG  Manufactured by : Dr.Reddy’s laboratories Package : 28 capsules  Category : Anti-neoplastic agent Azel 40mg tablet DOSAGE The usual prescribed dosage of Azel is 160mg as a single dose by taking with or without food. Azel is available in the strength of 40mg; four Capsules of Azel should be administered at a same time. Azel Capsule should not crush, not chew taken with glass of water. Dose adjustment: In patients with ≥ grade III toxicity: Azel 40mg therapy should be refuse for one week or the symptoms should be reduced to grade II, then restart with same dose or decreased to 80m

Bdenza 40mg Bdenza is a hormonal therapy, for men who are all affected with prostate carcinoma in metastatic stage. Bdenza 40mg tablet capsules are majorly indicated for prostate carcinoma, which contains Enzalutamide, as an active component considered as non steroidal anti-androgen medication. Bdenza 40mg is involved in association with castration in the therapy of metastatic or long lasting castration resistant prostate cancer. Bdenza 40mg is a prescription medicine, the main ingredient which is used as enzalutamide, only prescribed by medical oncologist. PRODUCT DETAILS Brand name : Bdenza Active ingredient : Enzalutamide Strength : 40MG  Manufactured by : BDR pharmaceuticals Package : 28 capsules  Category : Anti-neoplastic agent Bdenza 40mg tablet DOSING CONDITIONS AND ADMINISTRATION The usual prescribed dosage of Bdenza is 160mg as a single dose by taking with or without food. Bdenza is available in the strength of 40mg; four capsules of B

Soranib 200mg Tablet Soranib belongs to a class of multi kinase inhibitors, the main ingredient which is used as sorafenib.  It is not used as curable medicine but Soranib is used to reduce the growth rate of cancer cells by barrier the actions of an aberrant protein signal transduction helps to develop the cancer cells. Soranib is mechanism by depleting the blood supply to the cancer cells and stop their division and production. PRODUCT DETAILS Brand Name               Soranib  Available Dose           200 mg Composition                Sorafenib Tosylate Manufactured by        Cipla Ltd  Dosage Form              Tablets  Packing                       Pack of 120 Tablets Soranib 200mg Tablet DRUG INTERACTION Soranib 200mg tablet interaction with carbamazepine + dexamethasone + Phenobarbital + phenytoin + rifamipicin leads to reduce in Sorafenib plasma concentration. Soranib interaction with doxorubicin and irinotecan will increase the plas

Sorafenat 200mg Tablet Sorafenat belongs to a class of multi kinase inhibitors, the main ingredient which is used as sorafenib. It is not used as curable medicine but Sorafenat is used to reduce the growth rate of cancer cells by barrier the actions of an aberrant protein signal transduction helps to develop the cancer cells. Sorafenat is mechanism by depleting the blood supply to the cancer cells and stopa their division and production. Sorafenat 200mg PRODUCT DETAILS Brand Name                Sorafenat  Available Dose            200 mg Composition                Sorafenib Tosylate  Manufactured by         Natco Pharma Ltd.  Dosage Form               Tablets  Packing                        Pack of 120 Tablets DRUG INTERACTION Sorafenat 200mg tablet interaction with carbamazepine + dexamethasone + Phenobarbital + phenytoin + rifamipicin leads to reduce in Sorafenib plasma concentration. Sorafenat interaction with doxorubicin and irinotec

Hertab 250mg Hertab 250mg tablets are classified as anti-cancer agent, which is orally active drug used for treating breast cancer. Chemically classified as quinazoline with strong anti-cancer effect and the tablet Hertab is a synthetic oral tablet. Normally targeted therapy or tyrosine kinase inhibitor drugs can increase the plasma amino transferase levels which may leads to liver injury. Hertab tablets are classified as: 1. Tyrosine kinase prohibitor 2. Stop the HER2/neu & epidermal growth factor receptor activity 3. Targeted therapy  4. Signal transduction prohibitor PRODUCT DETAILS Brand Name                  Hertab  Composition                  Lapatinib   Strength availability      250mg  Manufactured by           Hetero  Pack                              150 tablets DRUG INTERACTION The drug Hertab are prohibition of CYP3A4, CYP2C8 & P-gp drug transporters; weak inhibitor of CYP3A4. Interaction of Midazolam with H

Lanib 250mg Lanib consist of Lapatinib is primarily indicated for advanced breast cancer. Lanib is used in combination with capecitabine with Lanib tablets are usually indicated for the treatment of metastatic breast cancer patients in whose cancer cells expressed with EGFR 2 (HER2) and patients may already receive an anthracycline, taxane& Transtuzumab. PRODUCT DETAILS Brand Name                   Lanib  Composition                  Lapatinib  Strength availability      250mg  Manufactured by           BDR Pack                              120 tablets DRUG INTERACTION The drug Lanib are prohibition of CYP3A4, CYP2C8 & P-gp drug transporters; weak inhibitor of CYP3A4. Interaction of Midazolam withLanib, increases the exposure of Midazolam Interaction of Paclitaxelwill Increase in paclitaxel exposure occurs while concomitant with Lanib Digoxin interaction with Lanib then the Serum digoxin concentration should be examined periodically prior

Erlocip 150mg Erlocip  tablets consist of active ingredients known as Erlotinib (Generic Tarceva), that is considered as quinazoline derivative and anti-cancer agents that responses as a protein kinase prohibitors for EGFR related to tyrosine kinase. Erlocip  is majorly used in the treatment of non-small cell lung cancer and pancreatic carcinoma and also involved to treat various cancers.  Erlocip  is especially aimed the epidermal growth factor receptor tyrosine kinase. USES OF Erlocip Erlocip 150mg tablet  is indicated as continuance therapy, in patients with long lasting or metastasis non small cell lung carcinoma, whose disease has not get advance after four cycles with platinum based first line therapy.  Erlocip is used in this condition only after the failure of one prior chemotherapy regimen. No clinical advantages occur while using  Erlocip  with platinum based compounds like Carboplatin, gemcitabine or cisplatin. Erlotinib Side effects During the therapy, some un

ERLONAT Erlonat  tablets consist of active ingredients known as Erlotinib (Generic Tarceva), that is considered as quinazoline derivative and anti-cancer agents that responses as a protein kinase prohibitors for EGFR related to tyrosine kinase. Erlonat  is majorly used in the treatment of non-small cell lung cancer and pancreatic carcinoma and also involved to treat various cancers.  Erlonat  is especially aimed the epidermal growth factor receptor tyrosine kinase. PRODUCT DETAILS Trade name :   Erlonat Active ingredient :  Erlotinib Manufactured by :  Natco Pharma Strength :  150mg Pack :  30 tablets in a container USES OF Erlonat Non small cell lung cancer: Erlonat 150mg tablet  is indicated as continuance therapy, in patients with long lasting or metastasis non small cell lung carcinoma, whose disease has not get advance after four cycles with platinum based first line therapy.  Erlonat  is used in this condition only after the failure of one prior chemot