Lanib 250mg tablets: Lapatinib usage & side effects

Lanib 250mg


Lanib consist of Lapatinib is primarily indicated for advanced breast cancer.

Lanib is used in combination with capecitabine with Lanib tablets are usually indicated for the treatment of metastatic breast cancer patients in whose cancer cells expressed with EGFR 2 (HER2) and patients may already receive an anthracycline, taxane& Transtuzumab.

PRODUCT DETAILS


Brand Name                   Lanib 
Composition                  Lapatinib 
Strength availability      250mg 
Manufactured by           BDR
Pack                              120 tablets

DRUG INTERACTION

  • The drug Lanib are prohibition of CYP3A4, CYP2C8 & P-gp drug transporters; weak inhibitor of CYP3A4.
  • Interaction of Midazolam withLanib, increases the exposure of Midazolam
  • Interaction of Paclitaxelwill Increase in paclitaxel exposure occurs while concomitant with Lanib
  • Digoxin interaction with Lanib then the Serum digoxin concentration should be examined periodically prior starting the concomitant use
  • Drug that induce or inhibit CYP3A4 enzymes:
  • If the interaction of Lanib 250mg tablets with CYP3A4 inducers or inhibitors, alteration of dose is necessary.
  • Interaction of Ketaconazole with Lanib, the dose reduced to 200mg as two times a day for 7 days.
  • Interaction of Carbamazepine with Lanib, the dose of carbamazepine at 100mg as a two times a day for 3 days & 200mg for two times a day for 17 days, the exposure of Lanib reduced to 72%.
  • Concomitant use of Lanib with P-gp inhibitors causes increasing the concentration of Lapatinib

CONTRAINDICATION:

The patients who are contraindicated to the component present in Lanib tablet then Hypersentivity reaction occurs.


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