Hertab 250mg tablet - Lapatinib Uses & Side effects

Hertab 250mg


Hertab 250mg tablets are classified as anti-cancer agent, which is orally active drug used for treating breast cancer.
Chemically classified as quinazoline with strong anti-cancer effect and the tablet Hertab is a synthetic oral tablet. Normally targeted therapy or tyrosine kinase inhibitor drugs can increase the plasma amino transferase levels which may leads to liver injury.

Hertab tablets are classified as:

1. Tyrosine kinase prohibitor
2. Stop the HER2/neu & epidermal growth factor receptor activity
3. Targeted therapy 
4. Signal transduction prohibitor


PRODUCT DETAILS


Brand Name                  Hertab 
Composition                  Lapatinib 
Strength availability      250mg 
Manufactured by           Hetero 
Pack                              150 tablets


DRUG INTERACTION


  • The drug Hertab are prohibition of CYP3A4, CYP2C8 & P-gp drug transporters; weak inhibitor of CYP3A4.
  • Interaction of Midazolam with Hertab, increases the exposure of Midazolam
  • Interaction of Paclitaxel Will Increase in paclitaxel exposure occurs while concomitant with Hertab. 
  • Digoxin interaction with Hertab then the Serum digoxin concentration should be examined periodically prior starting the concomitant use.
  • Drug that induce or inhibit CYP3A4 enzymes:
  • If the interaction of Hertab tablets with CYP3A4 inducers or inhibitors, alteration of dose is necessary.
  • Interaction of Ketoconazole with Hertab, the dose reduced to 200mg as two times a day for 7 days.
  • Interaction of Carbamazepine with Hertab, the dose of carbamazepine at 100mg as two times a day for 3 days & 200mg for two times a day for 17 days, the exposure of Hertab reduced to 72%.
  • Concomitant use of Hertab with P-gp inhibitors causes increasing the concentration of Lapatinib.

CONTRAINDICATION


The patients who are contraindicated to the component present in Hertab tablet then Hypersentivity reaction occurs.

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